TGF-beta 抗体
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北京 101111
Quick Overview for TGF-beta 抗体 (ABIN3023878)
抗原
See all TGF-beta (TGFb) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
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纯化方法
- Protein G affinity chromatography
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免疫原
- Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
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亚型
- IgG1 kappa
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anti-TGF-beta (TGFb) (AA 301-350) antibody
TGFb 适用: 人, 小鼠, 大鼠, 兔, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, Mink, Mustelid WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal TB21 unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, 兔, 哺乳动物 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人 ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal TB21 unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 犬, Hamster, 猴 ELISA, Func, D, ELISA (Capture) 宿主: 小鼠 Monoclonal TGFB-510 unconjugated
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应用备注
- Optimal dilution of the TGF-beta antibody should be determined by the researcher.\. Functional Activity: Cytokine Neutralization (Order SAF formulation)
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the TGF-beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- TGF-beta (TGFb)
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别名
- TGF-beta
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背景
- This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
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途径
- EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
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