Sos 抗体
适用: 人, 小鼠, Non-Human Primate
WB, ICC
宿主: 小鼠
Monoclonal
SOS-01
unconjugated
-
- 抗原
- Sos
- 适用
- 人, 小鼠, Non-Human Primate
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Western Blotting (WB), Immunocytochemistry (ICC)
- 特异性
- The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.
- 交叉反应 （详细）
- Human, Mouse, Other not determined
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
- 克隆位点
- SOS-01
- 亚型
- IgG1
-
-
- 应用备注
- Western blotting: Recommended dilution: 1 μg/mL, positive control: HeLa human cervix carcinoma cell line, reducing conditions.
- 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
-
- 抗原
- Sos
- 背景
- SOS Ras/Rac guanine nucleotide exchange factor 1,The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.,SOS1, HGF, GGF1
- 基因ID
- 6654
- UniProt
- Q07889
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