Sos 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in WB 和 ICC. Suitable for 人, 小鼠 和 Non-Human Primate.
Quick Overview for Sos 抗体 (ABIN302096)
抗原
Sos
适用
人, 小鼠, Non-Human Primate
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunocytochemistry (ICC)
克隆位点
SOS-01
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原理
- Anti-SOS Purified
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特异性
- The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.
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交叉反应 （详细）
- Human, Mouse, Other not determined
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
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亚型
- IgG1
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应用备注
- Western blotting: Recommended dilution: 1 μg/mL, positive control: HeLa human cervix carcinoma cell line, reducing conditions.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- Sos
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背景
- SOS Ras/Rac guanine nucleotide exchange factor 1,The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.,SOS1, HGF, GGF1
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基因ID
- 6654
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UniProt
- Q07889
抗原
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