TXN 抗体
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北京 101111
Quick Overview for TXN 抗体 (ABIN3020582)
抗原
See all TXN 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant full length protein Trx
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亚型
- IgG
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anti-Thioredoxin (TXN) (AA 1-105) antibody
TXN 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 2A7 unconjugated
anti-Thioredoxin (TXN) (C-Term) antibodyTXN 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Thioredoxin (TXN) (AA 2-105) antibodyTXN 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Thioredoxin (TXN) (AA 1-105) antibodyTXN 适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Thioredoxin (TXN) (AA 1-105) antibodyTXN 适用: 人 WB 宿主: 小鼠 Monoclonal 3# unconjugated
anti-Thioredoxin (TXN) (AA 66-94), (C-Term) antibodyTXN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB42816 unconjugated
anti-Thioredoxin (TXN) (AA 51-105) antibodyTXN 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Thioredoxin (TXN) antibodyTXN 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Thioredoxin (TXN) antibodyTXN 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB7270 unconjugated
anti-Thioredoxin (TXN) (AA 1-105) antibodyTXN 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilutions: WB: 1:1000-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C/-80 °C
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- TXN (Thioredoxin (TXN))
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别名
- Trx
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背景
- Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkappaB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. Thioredoxin 2 (Trx-2) is a small redox protein that is localized to the mitochondria and is essential for cell viability, playing a crucial role in the scavenging of ROS in mitochondria and regulating the mitochondrial apoptosis signaling pathway. Trx reductases (TrxR1 and TrxR2) are ubiquitously expressed flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
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途径
- Carbohydrate Homeostasis, Cell RedoxHomeostasis
抗原
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