LCK 抗体 (pTyr505)
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北京 101111
Quick Overview for LCK 抗体 (pTyr505) (ABIN3020028)
抗原
See all LCK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr505
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序列
- GQYQP
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交叉反应
- 人
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产品特性
- Phosphorylated Antibodies
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免疫原
- A synthetic phosphorylated peptide around Y505 of human Lck (NP_001036236.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IP,1:50 - 1:100
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))
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别名
- LCK
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背景
- This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.,LCK,IMD22,LSK,YT16,p56lck,pp58lck,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Centrosome,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Protein phosphorylation,LCK
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分子量
- 40 kDa/58 kDa/61 kDa
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基因ID
- 3932
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UniProt
- P06239
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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