ANO1 抗体 (AA 904-986)
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Quick Overview for ANO1 抗体 (AA 904-986) (ABIN2962568)
抗原
See all ANO1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 904-986
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特异性
- Reacts with human DOG1.
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纯化方法
- Purified (protein G)
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免疫原
- Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6).
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亚型
- IgG1
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 - 10 μg/mL) -
限制
- 仅限研究用
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缓冲液
- PBS, pH 7.4
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注意事项
- Dilute in PBS or medium which is identical to that used in the assay system.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
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- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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别名
- DOG1
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背景
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DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.
Anoctamin 1, ANO1 Calcium activated chloride channel Discovered on gastrointestinal stromal tumors protein 1 Oral cancer overexpressed protein 2, ORAOV2 Transmembrane protein 16A, TMEM16A Tumor-amplified and overexpressed sequence 2, TAOS2 Gene name : ANO1 -
基因ID
- 55107
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UniProt
- Q5XXA6
抗原
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