Oncostatin M 抗体
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北京 101111
Quick Overview for Oncostatin M 抗体 (ABIN289518)
抗原
See all Oncostatin M (OSM) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified
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免疫原
- Oncostatin M antibody was raised in rabbit using highly pure recombinant human oncostatin M as the immunogen.
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应用备注
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ELISA: 0.5-2 µg/mL, Inhibition: 0.1-0.175 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in sterile water to a concentration of > 0.2 mg/mL.
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浓度
- Lot specific
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缓冲液
- Lyophilized from 0.5 x PBS, pH 7.4.
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
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- Oncostatin M (OSM)
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别名
- Oncostatin M
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背景
- Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL6, and CNTF. Human OSM is active on Mouse cells.
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分子量
- 23.9 kDa (predicted detection band MW)
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途径
- JAK/STAT Signaling, Negative Regulation of Hormone Secretion
抗原
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