PGE2 抗体
Quick Overview for PGE2 抗体 (ABIN2869135)
抗原
See all PGE2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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免疫原
- PGE2 covalently coupled to carrier protein
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应用备注
- For Immunoassay Use
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说明
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Mouse Monoclonal to Prostaglandin E2 (PGE2) Extend primary antibody supplies Clone 5A2
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限制
- 仅限研究用
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缓冲液
- 100 mM Sodium Phosphate, 150 mM Sodium Chloride, 0.09 % Na Azide, pH 7.2
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- PGE2 (Prostaglandin E2 (PGE2))
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别名
- Prostaglandin E2
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背景
- Eicosanoid signal transduction pathways are highly conserved and are involved in a number of physiological processes. Prostaglandins are synthesized from arachidonic acid by cyclooxygenase (COX)-1 or -2, which con- vert the acid into PGH2. This is further processed by cytosolic or microsomal prostaglandin synthases to become PGE2 or one of several other prostanoids. Prostacyclin is the major cyclooxygenase product in blood vessel walls and it is present in inflammatory fluids in similar concentrations to PGE2. Prostacyclin is a potent vasodilator and is more potent than PGE2 in producing hyperalgesia. PGE2 is produced by a wide variety of tissues and in several pathological conditions, including inflammation, arthritis, fever, tissue injury, endometriosis, and a variety of cancers. Other biological actions of PGE2 include vasodilation, modulation of sleep/wake cycles, and facilitation of human immunodeficiency virus replication. It elevates cAMP levels, stimulates bone resorption, and has thermoregula- tory effects. It has been shown to be a regulator of sodium excretion and renal hemodynamics.
抗原
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