FBXL3 抗体
Quick Overview for FBXL3 抗体 (ABIN2856775)
抗原
See all FBXL3 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to FBXL3 (F-box and leucine-rich repeat protein 3)
FBXL3 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human FBXL3. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: C2C12 , Molt-4
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.41 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor." in: Nature communications, Vol. 8, pp. 14002, (2018) (PubMed).
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: "The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor." in: Nature communications, Vol. 8, pp. 14002, (2018) (PubMed).
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- FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))
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别名
- F-box and leucine rich repeat protein 3
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背景
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.
Cellular Localization: Nucleus , Cytoplasm -
分子量
- 49 kDa
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基因ID
- 26224
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UniProt
- Q9UKT7
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途径
- Photoperiodism
抗原
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