RAMP2 抗体 (C-Term)
(2 references)Quick Overview for RAMP2 抗体 (C-Term) (ABIN2856615)
抗原
See all RAMP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to RAMP2 (receptor (G protein-coupled) activity modifying protein 2)
RAMP2 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP2. The exact sequence is proprietary.
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亚型
- IgG
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anti-Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2) (AA 1-145) antibody
RAMP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2) (AA 43-145) antibodyRAMP2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2) (AA 54-68), (Extracellular) antibodyRAMP2 适用: 大鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2) (AA 43-145) antibodyRAMP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2) (AA 58-145) antibodyRAMP2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2F5 unconjugated
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Validation: Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion." in: Journal of molecular neuroscience : MN, Vol. 70, Issue 6, pp. 930-944, (2020) (PubMed).
: "Evidence for a functional adrenomedullin signaling pathway in the mouse retina." in: Molecular vision, Vol. 18, pp. 1339-53, (2012) (PubMed).
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: "Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion." in: Journal of molecular neuroscience : MN, Vol. 70, Issue 6, pp. 930-944, (2020) (PubMed).
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- RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))
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别名
- receptor activity modifying protein 2
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背景
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The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Cellular Localization: Membrane, Single-pass type I membrane protein -
分子量
- 20 kDa
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基因ID
- 10266
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UniProt
- O60895
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途径
- cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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