LIMK2 抗体
Quick Overview for LIMK2 抗体 (ABIN2856539)
抗原
See all LIMK2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
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Rabbit Polyclonal antibody to LIM kinase 2 (LIM domain kinase 2)
LIM kinase 2 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human LIM kinase 2. The exact sequence is proprietary.
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亚型
- IgG
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anti-LIM Domain Kinase 2 (LIMK2) (pSer283) antibody
LIMK2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 1-686) antibodyLIMK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2H2-E11 unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (pThr505) antibodyLIMK2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 1-686) antibodyLIMK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (Ser283) antibodyLIMK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 1-240) antibodyLIMK2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 181-193) antibodyVerified LIMK2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 1-686) antibodyLIMK2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 1-240) antibodyLIMK2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-LIM Domain Kinase 2 (LIMK2) (AA 461-510) antibodyLIMK2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- LIMK2 (LIM Domain Kinase 2 (LIMK2))
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别名
- LIM domain kinase 2
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背景
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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Cellular Localization: Isoform LIMK2a: Cytoplasm , Nucleus , Isoform LIMK2b: Cytoplasm -
分子量
- 72 kDa
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基因ID
- 3985
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UniProt
- P53671
抗原
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