AKR1C1 抗体
Quick Overview for AKR1C1 抗体 (ABIN2856139)
抗原
See all AKR1C1 (DDH) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
- 
    - 
                                            交叉反应
- 人, 小鼠
- 
                                            产品特性
- 
                        Rabbit Polyclonal antibody to AKR1C1 (aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase))
 AKR1C1 antibody
- 
                                            纯化方法
- Purified by antigen-affinity chromatography.
- 
                                            免疫原
- Recombinant protein encompassing a sequence within the center region of human AKR1C1. The exact sequence is proprietary.
- 
                                            亚型
- IgG
 
- 
                                            
- 
    
- 
    - 
                                            应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 
                                            说明
- 
                        Positive Control: mouse liver , A549 , AKR1C1-transfected 293T Validation: KO/KD, Orthogonal, Overexpression 
- 
                                            限制
- 仅限研究用
 
- 
                                            
- 
    - 
                                            状态
- Liquid
- 
                                            浓度
- 0.6 mg/mL
- 
                                            缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- 
                                            储存液
- ProClin
- 
                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            储存条件
- 4 °C,-20 °C
- 
                                            储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
- 
                                            
- 
    - 
                                            : "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer."    in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020)         (PubMed).        
 : "Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism." in: Frontiers in physiology, Vol. 10, pp. 833, (2019) (PubMed).
 : "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).
 
 
- 
                                            : "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer."    in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020)         (PubMed).        
- 
    - AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))
- 
                                            别名
- aldo-keto reductase family 1 member C1
- 
                                            背景
- 
                        This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. 
 Cellular Localization: Cytoplasm
- 
                                            分子量
- 37 kDa
- 
                                            基因ID
- 1645
- 
                                            UniProt
- Q04828
- 
                                            途径
- Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process
 抗原
- 
                    
 
                                     
                                     
                                    