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AKR1C1 抗体

This anti-AKR1C1 antibody (ABIN2856139) is a Rabbit Polyclonal antibody detecting AKR1C1 in WB, IHC, IHC (p), IF, ICC. Suitable for Human.
产品编号 ABIN2856139
发货至: 中国

Quick Overview for AKR1C1 抗体 (ABIN2856139)

抗原

See all AKR1C1 (DDH) 抗体
AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

适用

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宿主

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克隆类型

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多克隆

标记

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This AKR1C1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

质量等级

KO Validated
  • 交叉反应

    人, 小鼠

    产品特性

    Rabbit Polyclonal antibody to AKR1C1 (aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase))
    AKR1C1 antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human AKR1C1. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: mouse liver , A549 , AKR1C1-transfected 293T

    Validation: KO/KD, Orthogonal, Overexpression

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.6 mg/mL

    缓冲液

    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Zhu, Hu, Zeng, Chang, Ge, Wang, Yan, Zhao, Cao, Ying, Gu, Zheng, He, Yang: "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer." in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020) (PubMed).

    Zeng, Zhu, You, Dong, Yang, Zhu, He: "Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism." in: Frontiers in physiology, Vol. 10, pp. 833, (2019) (PubMed).

    Zhu, Chang, Yan, Hu, Zeng, Zhou, Yuan, Ying, Cao, He, Yang: "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).

  • 抗原

    AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

    别名

    aldo-keto reductase family 1 member C1

    背景

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

    Cellular Localization: Cytoplasm

    分子量

    37 kDa

    基因ID

    1645

    UniProt

    Q04828

    途径

    Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process
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