AKR1C1 抗体
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北京 101111
Quick Overview for AKR1C1 抗体 (ABIN2856139)
抗原
See all AKR1C1 (DDH) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to AKR1C1 (aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase))
AKR1C1 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human AKR1C1. The exact sequence is proprietary.
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亚型
- IgG
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anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-110) antibody
DDH 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-323) antibodyDDH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-323) antibodyDDH 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-110) antibodyDDH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-323) antibodyDDH 适用: 人 WB, ELISA, IF, ICC, FACS 宿主: 小鼠 Monoclonal AT6D10 unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) antibodyDDH 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal AT6D10 unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 1-323) antibodyDDH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (AA 219-323) antibodyDDH 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) antibodyDDH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Dihydrodiol Dehydrogenase (DDH) (N-Term) antibodyDDH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: mouse liver , A549 , AKR1C1-transfected 293T
Validation: KO/KD, Orthogonal, Overexpression
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.6 mg/mL
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缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer." in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020) (PubMed).
: "Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism." in: Frontiers in physiology, Vol. 10, pp. 833, (2019) (PubMed).
: "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).
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: "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer." in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020) (PubMed).
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- AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))
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别名
- aldo-keto reductase family 1 member C1
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背景
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Cellular Localization: Cytoplasm -
分子量
- 37 kDa
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基因ID
- 1645
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UniProt
- Q04828
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途径
- Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process
抗原
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