RASGRP4 抗体 (N-Term)
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- 抗原 See all RASGRP4 抗体
- RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RASGRP4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 交叉反应
- 人
- 产品特性
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Rabbit Polyclonal antibody to RASGRP4 (RAS guanyl releasing protein 4)
RASGRP4 antibody [N1N2], N-term - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RASGRP4. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product RASGRP4 Primary Antibody
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anti-RAS Guanyl Releasing Protein 4 (RASGRP4) (AA 574-673) antibody
RASGRP4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F3 unconjugated
anti-RAS Guanyl Releasing Protein 4 (RASGRP4) (AA 1-673) antibodyRASGRP4 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 4 (RASGRP4) (AA 149-198) antibodyRASGRP4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 4 (RASGRP4) (N-Term) antibodyRASGRP4 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: Jurkat
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))
- 别名
- RAS guanyl releasing protein 4 (RASGRP4 产品)
- 别名
- RASGRP4 antibody, RAS guanyl releasing protein 4 antibody, RASGRP4 antibody, rasgrp4 antibody, Rasgrp4 antibody
- 背景
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The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.
Cellular Localization: Cytoplasm , Cell membrane - 分子量
- 75 kDa
- 基因ID
- 115727
- UniProt
- Q8TDF6
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
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