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B-Cell Linker 抗体 (C-Term)

This anti-B-Cell Linker antibody is a 兔 多克隆 antibody detecting B-Cell Linker in WB, IF 和 ICC. Suitable for 人.
产品编号 ABIN2855863
发货至: 中国

Quick Overview for B-Cell Linker 抗体 (C-Term) (ABIN2855863)

抗原

See all B-Cell Linker (BLNK) 抗体
B-Cell Linker (BLNK)

适用

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宿主

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克隆类型

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多克隆

标记

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This B-Cell Linker antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
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    C-Term

    交叉反应

    产品特性

    Rabbit polyclonal antibody to B-cell linker protein (B-cell linker)
    B-cell linker protein antibody [C3], C-term

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BLNK. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: HeLa

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    B-Cell Linker (BLNK)

    别名

    B cell linker

    背景

    This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Cellular Localization: Cytoplasm , Cell membrane

    分子量

    50 kDa

    基因ID

    29760

    UniProt

    Q8WV28

    途径

    BCR Signaling
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