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PON2 抗体

This anti-PON2 antibody is a 兔 多克隆 antibody detecting PON2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2855759
发货至: 中国

Quick Overview for PON2 抗体 (ABIN2855759)

抗原

See all PON2 抗体
PON2 (Paraoxonase 2 (PON2))

适用

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宿主

  • 53
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  • 1

克隆类型

  • 48
  • 12
多克隆

标记

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This PON2 antibody is un-conjugated

应用范围

  • 40
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 交叉反应

    人, 小鼠

    产品特性

    Rabbit Polyclonal antibody to PON2 (paraoxonase 2)
    PON2 antibody [N1C2]

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human PON2. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A431 , Mouse liver

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Devarajan, Su, Grijalva, Yalamanchi, Yalamanchi, Gao, Trost, Nwokedi, Farias-Eisner, Farias-Eisner, Fogelman, Reddy: "Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer." in: Cell death & disease, Vol. 9, Issue 3, pp. 392, (2019) (PubMed).

  • 抗原

    PON2 (Paraoxonase 2 (PON2))

    别名

    paraoxonase 2

    背景

    This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

    Cellular Localization: Membrane, Peripheral membrane protein

    分子量

    39 kDa

    基因ID

    5445

    UniProt

    Q15165
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