CD22 抗体
Quick Overview for CD22 抗体 (ABIN2855664)
抗原
See all CD22 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人
-
产品特性
-
Rabbit polyclonal antibody to CD22 (CD22 Molecule)
CD22 antibody [N2C3] -
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein encompassing a sequence within the center region of human CD22. The exact sequence is proprietary.
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
说明
-
Positive Control: Raji
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- CD22 (CD22 Molecule (CD22))
-
别名
- CD22 molecule
-
背景
-
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Cellular Localization: Cell membrane -
分子量
- 95 kDa
-
基因ID
- 933
-
UniProt
- P20273
抗原
-