TOP2B 抗体 (C-Term)
Quick Overview for TOP2B 抗体 (C-Term) (ABIN2855447)
抗原
See all TOP2B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
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Rabbit Polyclonal antibody to Topoisomerase II beta (topoisomerase (DNA) II beta 180 kDa)
Topoisomerase II beta antibody [C3], C-term -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human Topoisomerase II beta. The exact sequence is proprietary.
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亚型
- IgG
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anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 446-655) antibody
TOP2B 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibodyTOP2B 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1400-1626) antibodyTOP2B 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibodyTOP2B 适用: 人, 犬, 猴, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1411-1523) antibodyTOP2B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (C-Term) antibodyTOP2B 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1548-1597) antibodyTOP2B 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 猴, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1439-1488) antibodyTOP2B 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 猴, Pig, 兔, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (Middle Region) antibodyTOP2B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (Middle Region) antibodyTOP2B 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: Jurkat , K562 , THP-1
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.48 mg/mL
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缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
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别名
- DNA topoisomerase II beta
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背景
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants, however, the second variant has not yet been fully described.
Cellular Localization: Cytoplasm , Nucleus , nucleolus -
分子量
- 183 kDa
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基因ID
- 7155
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UniProt
- Q02880
抗原
-
