RAN 抗体
Quick Overview for RAN 抗体 (ABIN2855298)
抗原
See all RAN 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
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Rabbit Polyclonal antibody to RAN (RAN, member RAS oncogene family)
RAN antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human RAN. The exact sequence is proprietary.
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亚型
- IgG
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anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8D1A6 unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (N-Term) antibodyVerified RAN 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 2-216) antibodyRAN 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39) antibodyRAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-179) antibodyRAN 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibodyRAN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39), (N-Term) antibodyRAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20229 unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140) antibodyRAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 197-210) antibodyVerified RAN 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibodyRAN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- RAN (RAN, Member RAS Oncogene Family (RAN))
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别名
- RAN, member RAS oncogene family
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背景
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RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Cellular Localization: Nucleus , Cytoplasm , Melanosome -
分子量
- 24 kDa
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基因ID
- 5901
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UniProt
- P62826
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途径
- Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
抗原
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