POM121 抗体 (N-Term)
(5 references)Quick Overview for POM121 抗体 (N-Term) (ABIN2855297)
抗原
See all POM121 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to POM121 (POM121 membrane glycoprotein (rat))
POM121 antibody [N2N3] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the N-terminus region of human POM121. The exact sequence is proprietary.
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亚型
- IgG
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anti-POM121 Membrane Glycoprotein (POM121) antibody
POM121 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-POM121 Membrane Glycoprotein (POM121) antibodyPOM121 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-POM121 Membrane Glycoprotein (POM121) (AA 1197-1246) antibodyPOM121 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: A549
Validation: Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.16 mg/mL
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缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." in: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).
: "Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. ..." in: Cell, Vol. 174, Issue 5, pp. 1200-1215.e20, (2019) (PubMed).
: "Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons." in: Acta neuropathologica, Vol. 132, Issue 1, pp. 77-91, (2017) (PubMed).
: "Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin." in: Nucleus (Austin, Tex.), Vol. 6, Issue 1, pp. 40-54, (2015) (PubMed).
: "The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function." in: Molecular biology of the cell, Vol. 25, Issue 1, pp. 160-8, (2014) (PubMed).
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: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." in: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).
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- POM121 (POM121 Membrane Glycoprotein (POM121))
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别名
- POM121 transmembrane nucleoporin
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背景
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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Single-pass membrane protein , Endoplasmic reticulum membrane, Single-pass membrane protein (By similarity) -
分子量
- 128 kDa
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基因ID
- 9883
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UniProt
- Q96HA1
抗原
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