TALDO1 抗体 (N-Term)
Quick Overview for TALDO1 抗体 (N-Term) (ABIN2855282)
抗原
See all TALDO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit Polyclonal antibody to Transaldolase (transaldolase 1)
Transaldolase antibody -
纯化方法
- Affinity purified by Protein A.
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免疫原
- Recombinant protein encompassing a sequence within the N-terminus region of human Transaldolase. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: A431 , Mouse brain
Validation: Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 6.48 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers." in: Nature communications, Vol. 9, Issue 1, pp. 4274, (2018) (PubMed).
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: "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers." in: Nature communications, Vol. 9, Issue 1, pp. 4274, (2018) (PubMed).
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- TALDO1 (Transaldolase 1 (TALDO1))
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别名
- transaldolase 1
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背景
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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Cellular Localization: Cytoplasm -
分子量
- 38 kDa
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基因ID
- 6888
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UniProt
- P37837
抗原
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