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PAX8 抗体

This anti-PAX8 antibody is a Rabbit Polyclonal antibody detecting PAX8 in WB, IHC, IF, IHC (p), IP, ICC, ChIP. Suitable for Human. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2855097
发货至: 中国

Quick Overview for PAX8 抗体 (ABIN2855097)

抗原

See all PAX8 抗体
PAX8 (Paired Box 8 (PAX8))

适用

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宿主

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克隆类型

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多克隆

标记

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This PAX8 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

质量等级

KO Validated
  • 交叉反应

    犬, 人, 小鼠, 大鼠

    产品特性

    Rabbit Polyclonal antibody to PAX8 (paired box 8)
    PAX8 antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human PAX8. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: 293T nuclear extract , DDDDK-tagged PAX8-transfected 293T

    Validation: KO/KD, Orthogonal, Overexpression

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.87 mg/mL

    缓冲液

    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Shi, Yin, Cai, Yan, Jia, Ma, Zhang, Zhang, Gu, Zhang, Di, Zhuang: "PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors." in: eLife, Vol. 8, (2020) (PubMed).

    Sun, Lu, Wu, Ouyang, Xing, Hou, Shi, Wu: "PTEN-knockdown disrupts the morphology, growth pattern and function of Nthy-Ori 3-1 cells by downregulating PAX8 expression." in: Oncology letters, Vol. 18, Issue 6, pp. 6732-6740, (2019) (PubMed).

  • 抗原

    PAX8 (Paired Box 8 (PAX8))

    别名

    paired box 8

    背景

    This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described.

    Cellular Localization: Nucleus

    分子量

    48 kDa

    基因ID

    7849

    UniProt

    Q06710

    途径

    Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
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