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APOE 抗体 (N-Term)

This anti-APOE antibody is a 兔 多克隆 antibody detecting APOE in WB, ICC, IHC (p) 和 IF. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2855049
发货至: 中国

Quick Overview for APOE 抗体 (N-Term) (ABIN2855049)

抗原

See all APOE 抗体
APOE (Apolipoprotein E (APOE))

适用

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宿主

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克隆类型

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多克隆

标记

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This APOE antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
  • 抗原表位

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    N-Term

    交叉反应

    产品特性

    Rabbit Polyclonal antibody to Apolipoprotein E (apolipoprotein E)
    Apolipoprotein E antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the N-terminus region of human Apolipoprotein E. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A549 , human plasma

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ellis, Naugler, Nauglers, Parini, Mörk, Jorns, Zemack, Sandblom, Björkhem, Ericzon, Wilson, Strom, Grompe: "Mice with chimeric livers are an improved model for human lipoprotein metabolism." in: PLoS ONE, Vol. 8, Issue 11, pp. e78550, (2014) (PubMed).

  • 抗原

    APOE (Apolipoprotein E (APOE))

    别名

    apolipoprotein E

    背景

    Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

    Cellular Localization: Secreted

    分子量

    36 kDa

    基因ID

    348

    UniProt

    P02649

    途径

    Regulation of Cell Size, Lipid Metabolism
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