CBL 抗体 (C-Term)
Quick Overview for CBL 抗体 (C-Term) (ABIN2855019)
抗原
See all CBL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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产品特性
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Rabbit Polyclonal antibody to CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence)
CBL antibody [C2C3], C-term -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human CBL. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- Suggested dilution Reference ICC/IF 1:50-1:200* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:50-1:200* Western blot1:500-1:3000*
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说明
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Positive Control: THP-1 , *293T
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS, 40 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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别名
- CBL
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背景
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The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Cellular Localization: Cytoplasm -
分子量
- 100 kDa
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基因ID
- 867
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途径
- TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
抗原
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