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DMPK 抗体 (Center)

This anti-DMPK antibody is a 兔 多克隆 antibody detecting DMPK in WB 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN2854986
发货至: 中国

Quick Overview for DMPK 抗体 (Center) (ABIN2854986)

抗原

See all DMPK 抗体
DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

适用

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人, 小鼠

宿主

  • 53
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克隆类型

  • 55
  • 3
多克隆

标记

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This DMPK antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    Center

    产品特性

    Rabbit Polyclonal antibody to DMPK (dystrophia myotonica-protein kinase)
    DMPK antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human DMPK. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

    说明

    Positive Control: U87-MG , SK-N-SH , SK-N-AS

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

    别名

    DMPK

    背景

    The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

    分子量

    69 kDa

    基因ID

    1760

    途径

    Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development
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