Factor VII 抗体
Quick Overview for Factor VII 抗体 (ABIN2854983)
抗原
See all Factor VII (F7) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))
Factor VII antibody [N3C3] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.
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亚型
- IgG
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anti-Coagulation Factor VII (F7) (AA 42-169) antibody
F7 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 1-444) antibodyF7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 1-444) antibodyF7 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 209-444) antibodyF7 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 334-452) antibodyF7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 315-433) antibodyF7 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 334-452) antibodyF7 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 1# unconjugated
anti-Coagulation Factor VII (F7) (AA 193-447) antibodyF7 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor VII (F7) (AA 302-332) antibodyF7 适用: 人 WB 宿主: 兔 Polyclonal RB54990 unconjugated
anti-Coagulation Factor VII (F7) (AA 1-444) antibodyF7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: NIH-3T3
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2.32 mg/mL
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缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Factor VII (F7) (Coagulation Factor VII (F7))
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别名
- coagulation factor VII
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背景
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This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
Cellular Localization: Secreted -
分子量
- 52 kDa
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基因ID
- 2155
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UniProt
- P08709
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途径
- Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling
抗原
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