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GLA 抗体

This anti-GLA antibody is a 兔 多克隆 antibody detecting GLA in WB, IP 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2854962
发货至: 中国

Quick Overview for GLA 抗体 (ABIN2854962)

抗原

See all GLA 抗体
GLA (Galactosidase, alpha (GLA))

适用

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宿主

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克隆类型

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多克隆

标记

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This GLA antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

KO Validated
  • 特异性

    Knockdown/Knockout validation was supported by customer review data.

    交叉反应

    人, 大鼠

    产品特性

    Rabbit Polyclonal antibody to Galactosidase alpha (galactosidase, alpha)
    Galactosidase alpha antibody [N1C2]

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: HeLa , 293T , Rat lung

    Validation: KO/KD

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.157 mg/mL

    缓冲液

    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." in: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

    Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." in: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

  • 抗原

    GLA (Galactosidase, alpha (GLA))

    别名

    galactosidase alpha

    背景

    This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

    Cellular Localization: Lysosome

    分子量

    49 kDa

    基因ID

    2717

    UniProt

    P06280

    途径

    SARS-CoV-2 Protein Interactome
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