VHL 抗体
(1 reference)-
- 抗原 See all VHL 抗体
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VHL antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 交叉反应
- 人, 小鼠
- 产品特性
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Rabbit Polyclonal antibody to Von Hippel Lindau (von Hippel-Lindau tumor suppressor)
Von Hippel Lindau antibody - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human Von Hippel Lindau. The exact sequence is proprietary.
- 亚型
- IgG
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anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-172) antibody
VHL 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 43-71), (N-Term) antibodyVHL 适用: 人, 小鼠 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB18667 unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 43-71) antibodyVHL 适用: 人, 小鼠 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 6-175) antibodyVHL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 181-210), (C-Term) antibodyVHL 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18668 unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 181-210) antibodyVHL 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-110) antibodyVHL 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (Internal Region) antibodyVerified VHL 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, EIA 宿主: 山羊 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) antibodyVHL 适用: 人, 小鼠 WB, IHC, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-50) antibodyVHL 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
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Positive Control: Myc-DDK-tagged VHL-transfected 293T
Validation: Overexpression
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.27 mg/mL
- 缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
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: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
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- 抗原
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- 别名
- von Hippel-Lindau tumor suppressor (VHL 产品)
- 别名
- HRCA1 antibody, RCA1 antibody, VHL1 antibody, pVHL antibody, BcDNA:RH61560 antibody, CG13221 antibody, DVhl antibody, Dmel\\CG13221 antibody, Dvhl antibody, VHL antibody, d-VHL antibody, d-vhl antibody, dVHL antibody, dmVHL antibody, vhl antibody, rca1 antibody, vhl1 antibody, hrca1 antibody, zgc:158722 antibody, Vhlh antibody, von Hippel-Lindau tumor suppressor antibody, von Hippel-Lindau antibody, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase antibody, von Hippel-Lindau disease tumor suppressor antibody, VHL antibody, Vhl antibody, vhl antibody, CpipJ_CPIJ009992 antibody
- 背景
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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Cellular Localization: Isoform 1: Cytoplasm , Membrane, Peripheral membrane protein , Nucleus , Isoform 3: Cytoplasm - 分子量
- 24 kDa
- 基因ID
- 7428
- UniProt
- P40337
- 途径
- Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Ubiquitin Proteasome Pathway
