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ALPL 抗体 (Center)

ALPL 适用: 人, 小鼠, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854870
发货至: 中国
  • 抗原 See all ALPL 抗体
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    抗原表位
    • 16
    • 10
    • 9
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    适用
    • 79
    • 49
    • 17
    • 5
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 绵羊
    宿主
    • 76
    • 19
    • 1
    • 1
    克隆类型
    • 77
    • 20
    多克隆
    标记
    • 60
    • 9
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALPL antibody is un-conjugated
    应用范围
    • 69
    • 38
    • 25
    • 17
    • 13
    • 13
    • 13
    • 12
    • 11
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠, 猫, 犬, 大鼠, 牛
    交叉反应 (详细)
    Mouse (91 %), Cat (90 %), Dog (89 %), Rat (91 %), Bovine (89 %)
    产品特性
    Rabbit polyclonal antibody to alkaline phosphatase (liver/bone/kidney) (alkaline phosphatase, liver/bone/kidney)
    Alkaline Phosphatase (Tissue Non-Specific) antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Alkaline Phosphatase (Tissue Non-Specific). The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product ALPL Primary Antibody
  • 应用备注
    Suggested dilution Reference Immunohistochemistry Assay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceImmunohistochemistryAssay-dependent dilution IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    说明

    Positive Control: HeLa , HepG2 , Molt-4 , Raji

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.48 mg/mL
    缓冲液
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    储存液
    Thimerosal (Merthiolate)
    注意事项
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Agustina, Asyifa, Aziz, Hernowo: "The Role of Osteocalcin and Alkaline Phosphatase Immunohistochemistry in Osteosarcoma Diagnosis." in: Pathology research international, Vol. 2018, pp. 6346409, (2018) (PubMed).

  • 抗原
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    别名
    Alkaline Phosphatase (Liver/bone/kidney) (ALPL 产品)
    别名
    ALP antibody, iap antibody, alpl antibody, AP-TNAP antibody, APTNAP antibody, HOPS antibody, TNAP antibody, TNSALP antibody, Akp-2 antibody, Akp2 antibody, PHOA antibody, TNS-AP antibody, alkaline phosphatase, liver/bone/kidney L homeolog antibody, alkaline phosphatase, liver/bone/kidney antibody, alkaline phosphatase, intestinal, gene 2 antibody, alkaline phosphatase, liver/bone/kidney pseudogene antibody, alpl.L antibody, ALPL antibody, alpi.2 antibody, LOC100031702 antibody, Alpl antibody
    背景
    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

    Cellular Localization: Cell membrane, Lipid-anchor , GPI-anchor
    分子量
    57 kDa
    基因ID
    249
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