Cofilin 2 抗体 (C-Term)
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北京 101111
Quick Overview for Cofilin 2 抗体 (C-Term) (ABIN2854655)
抗原
See all Cofilin 2 (CFL2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠
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产品特性
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Rabbit polyclonal antibody to Cofilin 2 (cofilin 2 (muscle))
Cofilin 2 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Cofilin 2. The exact sequence is proprietary.
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亚型
- IgG
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anti-Cofilin 2 (CFL2) (AA 57-166) antibody
CFL2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6G9 unconjugated
anti-Cofilin 2 (CFL2) (C-Term) antibodyVerified CFL2 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (AA 1-166) antibodyCFL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (AA 121-153), (C-Term) antibodyCFL2 适用: 人, 小鼠, 大鼠 WB, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (AA 1-156) antibodyCFL2 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (AA 1-166) antibodyCFL2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (AA 130-144), (C-Term) antibodyCFL2 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB48609 unconjugated
anti-Cofilin 2 (CFL2) antibodyCFL2 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) (C-Term) antibodyCFL2 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 马, Pig, 猴, Bat, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Cofilin 2 (CFL2) antibodyCFL2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: Raji , Neuro2A , C8D30 , Raw264.7
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins." in: International journal of molecular sciences, Vol. 20, Issue 22, (2020) (PubMed).
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: "Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins." in: International journal of molecular sciences, Vol. 20, Issue 22, (2020) (PubMed).
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- Cofilin 2 (CFL2)
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别名
- cofilin 2
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背景
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Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH -dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN, MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190], Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]
Cellular Localization: Nucleus matrix , Cytoplasm , cytoskeleton -
分子量
- 19 kDa
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基因ID
- 1073
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UniProt
- Q9Y281
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途径
- Caspase Cascade in Apoptosis
抗原
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