IL12RB1 抗体
Quick Overview for IL12RB1 抗体 (ABIN2854451)
抗原
See all IL12RB1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
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Rabbit polyclonal antibody to IL-12R beta1(CD212) (interleukin 12 receptor, beta 1)
IL12 Receptor beta1 antibody [N1C2] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human IL12 Receptor beta1. The exact sequence is proprietary.
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亚型
- IgG
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anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 420-470) antibody
IL12RB1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) antibodyIL12RB1 适用: 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 1-381) antibodyIL12RB1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 37-234) antibodyIL12RB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) antibodyIL12RB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 197-348) antibodyIL12RB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 119-280) antibodyIL12RB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 1-381) antibodyIL12RB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (Internal Region) antibodyVerified IL12RB1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin 12 Receptor beta 1 (IL12RB1) (AA 25-305) antibodyIL12RB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: A431
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
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别名
- interleukin 12 receptor subunit beta 1
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背景
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The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Cellular Localization: Membrane, Single-pass type I membrane protein -
分子量
- 73 kDa
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基因ID
- 3594
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UniProt
- P42701
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
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