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IL1RL1 抗体 (FITC)

IL1RL1 适用: 人 FACS 宿主: 小鼠 Monoclonal 2A5 FITC
产品编号 ABIN2853578
发货至: 中国
  • 抗原 See all IL1RL1 抗体
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    适用
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    宿主
    • 49
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    小鼠
    克隆类型
    • 48
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    单克隆
    标记
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    This IL1RL1 antibody is conjugated to FITC
    应用范围
    • 31
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    Flow Cytometry (FACS)
    特异性
    This antibody reacts with ST2.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A agarose
    免疫原
    Secreted form of ST2 protein which were purified from culture supernatant of COS7 transfectant cells
    克隆位点
    2A5
    亚型
    IgG1
    Top Product
    Discover our top product IL1RL1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    50 tests in a 100 μL volume of PBS, 0.09 % NaN3, 1 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2 - 8 °C.
  • 抗原
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    别名
    IL1RL1 / ST2 (IL1RL1 产品)
    别名
    DER4 antibody, Fit-1 antibody, Ly84 antibody, ST2L antibody, St2 antibody, St2-rs1 antibody, T1 antibody, T1/ST2 antibody, FIT-1 antibody, IL33R antibody, ST2 antibody, ST2V antibody, FIT1 antibody, interleukin 1 receptor-like 1 antibody, interleukin 1 receptor like 1 antibody, Il1rl1 antibody, IL1RL1 antibody
    背景
    The ST2 gene, also known as T1, Fit1, or DER4, was originally identified as a responsive gene that was highly induced by stimulation of various proliferation-inducing agents including serum, PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), or lysophosphatidic acid in murine fibroblasts. Three distinct forms of gene products have been reported and named ST2, ST2V, and ST2L. ST2 is a soluble secreted form of a 37 kDa protein, which lacks an intracellular domain, whereas ST2L is a transmembrane form of a 62 kDa protein (the glycosylated forms of ST2 and ST2L are about 57 and 80 kDa, respectively). This ST2L protein is very similar to IL-1R (interleukin-1 receptor) type I and II in structure, thus it is considered a member of the IL-1R family. ST2V, which is another novel variant form of human ST2, has been identified recently. ST2 proteins are expressed in several types of human cells, including hematopoietic cells in various stages of differentiation, a population of the peripheral blood mononuclear cells from healthy individuals, glioblastoma and astrocytoma cell lines, and colon cancer cells in addition to fibroblast cell lines. Thus ST2 proteins are considered to have some roles in regulating cell growth or proliferation. On the other hand, definitive functions of ST2 proteins and their ligand molecule(s) which bind to ST2 proteins have remained unclear, though it has been reported that IL-1a, ß, RA (receptor antagonist) do not bind to ST2 proteins in spite of their structural similarity to IL-1R. This indicates that the ST2L protein is functionally independent from IL-1R. Furthermore, several studies have shown that ST2L is expressed on the cell surface of Th2 cells but not on Th1 cells, indicating the possibility that the ST2L protein participates not only in the regulation of cell growth or proliferation, but also in the immune system including differentiation of T cells or immunological response via helper T cells. From these observations, ST2 proteins are considered to be important proteins that participate in various physiological phenomenons, thus further analysis is required to understand its physiological functions.Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
    基因ID
    9173
    NCBI登录号
    NP_003847
    UniProt
    Q01638
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