HFE 抗体 (AA 262-348) (AbBy Fluor® 594)
Quick Overview for HFE 抗体 (AA 262-348) (AbBy Fluor® 594) (ABIN2808717)
抗原
See all HFE 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 262-348
-
交叉反应
- 人
-
预测反应
- Mouse,Rat,Dog,Cow,Sheep,Horse
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human HFE/Hemochromatosis
-
亚型
- IgG
-
-
anti-Hemochromatosis (HFE) (AA 115-205) antibody
HFE 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-Hemochromatosis (HFE) antibodyHFE 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 3F1 unconjugated
anti-Hemochromatosis (HFE) (AA 1-348) antibodyHFE 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (AA 262-348) antibodyHFE 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (Internal Region) antibodyHFE 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (AA 149-198) antibodyHFE 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (AA 80-306) antibodyHFE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (C-Term) antibodyHFE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (AA 35-84) antibodyHFE 适用: 人, 小鼠, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Hemochromatosis (HFE) (AA 1-348) antibodyHFE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- HFE (Hemochromatosis (HFE))
-
别名
- HFE/Hemochromatosis
-
背景
-
Synonyms: dJ221C16.10.1, Hemochromatosis, Hemochromatosis protein, Hereditary hemochromatosis protein, Hereditary hemochromatosis protein HLA H, HFE 1, HFE, HFE_HUMAN, HFE1, HH, High Fe, HLA H, HLA-H, HLAH, MGC:150812, MGC10379, MGC103790, MHC class I like protein HFE, MVCD7, TFQTL2.
Background: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with _2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
-
基因ID
- 3077
-
途径
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
-
