HBxAg 抗体 (AbBy Fluor® 594)
Quick Overview for HBxAg 抗体 (AbBy Fluor® 594) (ABIN2802664)
抗原
适用
宿主
克隆类型
标记
应用范围
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交叉反应
- Virus
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交叉反应 （详细）
- Hepatitis B virus
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from Hepatitis B virus X protein
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亚型
- IgG
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anti-Hepatitis B Virus X Antigen (HBxAg) antibody
HBxAg 适用: Hepatitis B Virus (HBV) WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF(IHC-P) 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- HBxAg (Hepatitis B Virus X Antigen (HBxAg))
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别名
- Hepatitis B Virus X Protein
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物质类
- Viral Protein
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背景
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Synonyms: HBX, pre-X protein, HB-X, X protein, HBV X protein, X protein [Hepatitis B virus].
Background: Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).
抗原
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