SIGLEC11 抗体 (C-Term)
Quick Overview for SIGLEC11 抗体 (C-Term) (ABIN2799004)
抗原
See all SIGLEC11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 631-662, C-Term
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原理
- Rabbit Anti-Human SIGLEC11 (C-term) Antibody
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免疫原
- This SIGLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-662 amino acids from the C-terminal region of human SIGLEC11.
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亚型
- Ig Fraction
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anti-Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) (AA 251-350) antibody
SIGLEC11 适用: 人 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11) (C-Term) antibodySIGLEC11 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50SIGLEC11 Antibody for immunohistochemistry. Clinical relevance has not been evaluated. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.310 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))
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别名
- SIGLEC11
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背景
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Target Description: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.
Gene Symbol: SIGLEC11
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分子量
- 75795 Da
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基因ID
- 114132
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UniProt
- Q96RL6
抗原
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