CRTC2 抗体 (N-Term)
Quick Overview for CRTC2 抗体 (N-Term) (ABIN2798540)
抗原
See all CRTC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 94-123, N-Term
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原理
- Rabbit Anti-Human CRTC2 (N-term) Antibody
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免疫原
- This CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the N-terminal region of human CRTC2.
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亚型
- Ig Fraction
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应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50CRTC2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.420 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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别名
- CRTC2
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背景
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Target Description: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Gene Symbol: CRTC2
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分子量
- 73302 Da
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基因ID
- 200186
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UniProt
- Q53ET0
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途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
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