GNAS 抗体 (C-Term)
Quick Overview for GNAS 抗体 (C-Term) (ABIN2798020)
抗原
See all GNAS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 287-315, C-Term
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原理
- Rabbit Anti-Human GNAS (C-term) Antibody
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免疫原
- This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS.
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亚型
- Ig Fraction
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应用备注
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Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50, IF: 1:10-50, FC: 1:10-50Western blot analysis of GNAS (arrow) using rabbit polyclonal GNAS Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.420 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- GNAS (GNAS Complex Locus (GNAS))
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别名
- GNAS
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背景
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Target Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
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UniProt
- Q5FWY2
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途径
- Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis
抗原
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