TBK (AA 150-181) 抗体
Quick Overview for TBK (AA 150-181) 抗体 (ABIN2793269)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-181
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原理
- Rabbit Anti-Human TBK (S172) Antibody
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免疫原
- This TBK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-181 amino acids from human TBK.
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亚型
- Ig Fraction
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anti-TBK (pSer172) antibody
适用: 人 DB 宿主: 兔 Polyclonal RB16573 unconjugated
anti-TBK antibody适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-TBK (pSer172) antibody适用: 人 DB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of anti-TBK Antibody (S172) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human testis tissue reacted with TBK-pS172, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- TBK
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背景
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Target Description: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Gene Symbol: TBK1
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分子量
- 83642 Da
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基因ID
- 29110
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UniProt
- Q9UHD2
抗原
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