GCM1 抗体 (N-Term)
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北京 101111
Quick Overview for GCM1 抗体 (N-Term) (ABIN2792608)
抗原
See all GCM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK
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交叉反应
- 犬, 人, 小鼠, 大鼠
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预测反应
- Dog: 78%, Human: 92%, Mouse: 78%, Rat: 78%
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产品特性
- This is a rabbit polyclonal antibody against GCM1. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GCM1
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anti-Glial Cells Missing Homolog 1 (GCM1) (AA 108-166) antibody
GCM1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E11 unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 108-166) antibodyGCM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (N-Term) antibodyGCM1 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 121-220) antibodyGCM1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 207-436) antibodyGCM1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (C-Term) antibodyGCM1 适用: 人, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (N-Term) antibodyGCM1 适用: 人, 小鼠, 兔, 豚鼠, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 26-121) antibodyGCM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 251-300) antibodyGCM1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glial Cells Missing Homolog 1 (GCM1) (C-Term) antibodyGCM1 适用: 人, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB Suggested Anti-GCM1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:7812500
Positive Control: Human Placenta.
Optimal working dilutions should be determined experimentally by the investigator. -
说明
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Antigen size: 436 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis." in: Cell death & disease, Vol. 8, Issue 2, pp. e2590, (2017) (PubMed).
: "Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 30152-62, (2015) (PubMed).
: "Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia." in: Endocrinology, Vol. 154, Issue 3, pp. 1296-309, (2013) (PubMed).
: "The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation." in: Molecular and cellular biology, Vol. 33, Issue 9, pp. 1782-96, (2013) (PubMed).
: "Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi." in: Human reproduction (Oxford, England), Vol. 26, Issue 5, pp. 1025-34, (2011) (PubMed).
: "Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast." in: Cell death and differentiation, Vol. 16, Issue 5, pp. 719-27, (2009) (PubMed).
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: "Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis." in: Cell death & disease, Vol. 8, Issue 2, pp. e2590, (2017) (PubMed).
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- GCM1 (Glial Cells Missing Homolog 1 (GCM1))
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别名
- GCM1 / GCMA
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背景
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GCM1 is a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-132 D88613.1 1-132 133-2763 AB026493.1 1-2631
Alias Symbols: GCMA, hGCMa
Protein Interaction Partner: FBXW2, UBC, SENP1, CAMK1, SUMO1, DUSP23, CREBBP, HDAC5, HDAC4, HDAC3, HDAC1, CUL1, SKP1, UBE2I,
Protein Size: 436 -
分子量
- 49 kDa
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基因ID
- 8521
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NCBI登录号
- NM_003643, NP_003634
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UniProt
- Q9NP62
抗原
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