我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

GCM1 抗体 (N-Term)

Name: GCM1 抗体 (N-Term)
SKU: ABIN2792608
Availability: OutOfStock

This anti-GCM1 antibody is a 兔多克隆 antibody detecting GCM1 in WB 和 IHC. Suitable for 人, 小鼠, 大鼠和犬. This Primary Antibody has been cited in 6+ publications.

WB Suggested Anti-GCM1 Antibody Titration: 0. (GCM1 抗体 (N-Term))

IHC

IHC

Host: Rabbit Target Name: GCM1 Sample Tissue: Human 293T Antibody Dilution: 1. (GCM1 抗体 (N-Term))

5 images

(6 references)

产品编号 ABIN2792608

发货至: 中国

Quick Overview for GCM1 抗体 (N-Term) (ABIN2792608)

抗原

See all GCM1 抗体

GCM1 (Glial Cells Missing Homolog 1 (GCM1))

适用

人, 小鼠, 大鼠, 犬

宿主

兔

克隆类型

多克隆

标记

This GCM1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

抗原表位
16

4

3

2

2

1

1

1
N-Term

序列

MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK

交叉反应

犬, 人, 小鼠, 大鼠

预测反应

Dog: 78%, Human: 92%, Mouse: 78%, Rat: 78%

产品特性

This is a rabbit polyclonal antibody against GCM1. It was validated on Western Blot and immunohistochemistry.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human GCM1
anti-Glial Cells Missing Homolog 1 (GCM1) (AA 108-166) antibody
GCM1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E11 unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (AA 108-166) antibody
GCM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C11 unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (N-Term) antibody
GCM1 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (AA 121-220) antibody
GCM1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (AA 207-436) antibody
GCM1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (C-Term) antibody
GCM1 适用: 人, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (N-Term) antibody
GCM1 适用: 人, 小鼠, 兔, 豚鼠, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (AA 26-121) antibody
GCM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G5 unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (AA 251-300) antibody
GCM1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Glial Cells Missing Homolog 1 (GCM1) (C-Term) antibody
GCM1 适用: 人, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB Suggested Anti-GCM1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:7812500
Positive Control: Human Placenta.
Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 436 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bailey, Alahari, Tagliaferro, Post, Caniggia: "Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis." in: Cell death & disease, Vol. 8, Issue 2, pp. e2590, (2017) (PubMed).

Moretto Zita, Soncin, Natale, Pizzo, Parast: "Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 30152-62, (2015) (PubMed).

Sivasubramaniyam, Garcia, Tagliaferro, Melland-Smith, Chauvin, Post, Todros, Caniggia: "Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia." in: Endocrinology, Vol. 154, Issue 3, pp. 1296-309, (2013) (PubMed).

Kumar, Luo, Tudela, Alexander, Mendelson: "The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation." in: Molecular and cellular biology, Vol. 33, Issue 9, pp. 1782-96, (2013) (PubMed).

Drewlo, Czikk, Baczyk, Lye, Kingdom: "Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi." in: Human reproduction (Oxford, England), Vol. 26, Issue 5, pp. 1025-34, (2011) (PubMed).

Baczyk, Drewlo, Proctor, Dunk, Lye, Kingdom: "Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast." in: Cell death and differentiation, Vol. 16, Issue 5, pp. 719-27, (2009) (PubMed).
抗原

GCM1 (Glial Cells Missing Homolog 1 (GCM1))

别名

GCM1 / GCMA

背景

GCM1 is a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-132 D88613.1 1-132 133-2763 AB026493.1 1-2631
Alias Symbols: GCMA, hGCMa
Protein Interaction Partner: FBXW2, UBC, SENP1, CAMK1, SUMO1, DUSP23, CREBBP, HDAC5, HDAC4, HDAC3, HDAC1, CUL1, SKP1, UBE2I,
Protein Size: 436

分子量

49 kDa

基因ID

8521

NCBI登录号

NM_003643, NP_003634

UniProt

Q9NP62