CHRNA7 抗体 (N-Term)
Quick Overview for CHRNA7 抗体 (N-Term) (ABIN2792250)
抗原
See all CHRNA7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- QGEFQRKLYK ELVKNYNPLE RPVANDSQPL TVYFSLSLLQ IMDVDEKNQV
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预测反应
- Cow: 93%, Human: 100%, Mouse: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against CHRNA7. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7
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anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 52-259) antibody
CHRNA7 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7F10G1 unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 441-502) antibodyCHRNA7 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 52-259) antibodyCHRNA7 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7F10F1 unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 23-230) antibodyCHRNA7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 23-230) antibodyCHRNA7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 31-42), (Extracellular) antibodyKO Validated CHRNA7 适用: 大鼠 WB, IHC, FACS, IF, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (Internal Region) antibodyVerified CHRNA7 适用: 人, 大鼠 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (C-Term) antibodyCHRNA7 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 398-447) antibodyCHRNA7 适用: 人, Cow, 小鸡, 猴, 马, Pig, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 22-71) antibodyCHRNA7 适用: 人, 大鼠, 小鼠, 猴, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 502 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
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别名
- CHRNA7
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背景
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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.
Alias Symbols: NACHRA7, CHRNA7-2
Protein Interaction Partner: ATXN1, ADCY6, PIK3R1, APP, FYN,
Protein Size: 502 -
分子量
- 56 kDa
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基因ID
- 1139
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NCBI登录号
- NM_000746, NP_000737
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UniProt
- P36544
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途径
- Synaptic Membrane
抗原
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