Cyclin T1 抗体 (N-Term)
(1 reference)Quick Overview for Cyclin T1 抗体 (N-Term) (ABIN2792158)
抗原
See all Cyclin T1 (CCNT1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- EGERKNNNKR WYFTREQLEN SPSRRFGVDP DKELSYRQQA ANLLQDMGQR
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预测反应
- Cow: 100%, Dog: 92%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against CCNT1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human CCNT1
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anti-Cyclin T1 (CCNT1) (AA 375-410), (Middle Region) antibody
CCNT1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (AA 253-281) antibodyCCNT1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB19562 unconjugated
anti-Cyclin T1 (CCNT1) (AA 256-285), (Middle Region) antibodyCCNT1 适用: 人, 小鼠 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (AA 1-726) antibodyCCNT1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (AA 466-680) antibodyCCNT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (Internal Region) antibodyVerified CCNT1 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (N-Term) antibodyCCNT1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, Pig, 豚鼠, 兔, 猴, 非洲爪蟾, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (AA 220-320) antibodyCCNT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin T1 (CCNT1) (N-Term) antibodyCCNT1 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 非洲爪蟾, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 726 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide" in: Journal of virology, Vol. 82, Issue 11, pp. 5562-72, (2008) (PubMed).
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: "Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide" in: Journal of virology, Vol. 82, Issue 11, pp. 5562-72, (2008) (PubMed).
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- Cyclin T1 (CCNT1)
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别名
- CCNT1
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背景
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CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CCNT, CYCT1, HIVE1
Protein Interaction Partner: tat, LARP7, AFF1, CDK9, BRD4, HEXIM1, UBC, SUMO1, NEDD8, RN7SK, SUPT5H, SOX2, CTD, MBP, AFF4, ELL2, MED26, MLLT3, ESR1, DAB2, CCNT1, BRDT, BARD1, TAF1, RPS9, GNAI3, LEO1, C11orf58, TUBB4B, TP53BP1, KMT2A, UBE2A, POLR2A, GTF2F1, TAF7, Ep300, Gata4, TERF2,
Protein Size: 726 -
分子量
- 81 kDa
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基因ID
- 904
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NCBI登录号
- NM_001240, NP_001231
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UniProt
- O60563
抗原
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