NLRC4 抗体 (C-Term)
(1 reference)Quick Overview for NLRC4 抗体 (C-Term) (ABIN2792097)
抗原
See all NLRC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- QLNLAGNRVS SDGWLAFMGV FENLKQLVFF DFSTKEFLPD PALVRKLSQV
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特异性
- This antibody will recognize NLRC4 isoform 1 (116kD) and isoform 2 (40kD).
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预测反应
- Guinea Pig: 80%, Human: 100%, Mouse: 86%, Rat: 80%
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产品特性
- This is a rabbit polyclonal antibody against NLRC4. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human NLRC4
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anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody
NLRC4 适用: 人, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 1-250) antibodyNLRC4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (pSer533) antibodyNLRC4 适用: 人 ELISA, ICC, FACS 宿主: 大鼠 Monoclonal 9A6A1 unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (pSer533) antibodyNLRC4 适用: 人, 小鼠 WB, ELISA, ICC 宿主: 大鼠 Monoclonal 4B7B7 unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibodyNLRC4 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibodyNLRC4 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 941-990) antibodyNLRC4 适用: 人, 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (N-Term) antibodyNLRC4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 1-250) antibodyNLRC4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 531-630) antibodyNLRC4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1024 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation." in: American journal of physiology. Renal physiology, Vol. 306, Issue 3, pp. F299-308, (2014) (PubMed).
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: "Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation." in: American journal of physiology. Renal physiology, Vol. 306, Issue 3, pp. F299-308, (2014) (PubMed).
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- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
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别名
- NLRC4
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背景
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In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Alias Symbols: CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CARD12, CLR2.1
Protein Interaction Partner: UBC, XK, ALB, NLRC4, PSMC5, CASP8, NLRP4, PYCARD, NOD2, BCL10, CASP1, NLRP1, NLRP3, NOD1, NAIP,
Protein Size: 1024 -
分子量
- 116 kDa
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基因ID
- 58484
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NCBI登录号
- NM_021209, NP_067032
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UniProt
- Q9NPP4
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途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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