Oncogene Protein p190/bcr-Abl (N-Term) 抗体
The 兔 多克隆 anti-Oncogene Protein p190/bcr-Abl antibody is suitable to detect Oncogene Protein p190/bcr-Abl in samples from 人, Cow, 犬, 豚鼠, 马, 小鼠, 兔, 大鼠 和 斑马鱼. It has been validated for WB.
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产品编号 ABIN2792051
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Oncogene Protein p190/bcr-Abl (N-Term) 抗体 (ABIN2792051)
抗原
Oncogene Protein p190/bcr-Abl
适用
人, Cow, 犬, 豚鼠, 马, 小鼠, 兔, 大鼠, 斑马鱼
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB)
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抗原表位
- N-Term
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序列
- EDFSSGQSSR VSPSPTTYRM FRDKSRSPSQ NSQQSFDSSS PPTPQCHKRH
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against BCR-ABL1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of human BCR
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Oncogene Protein p190/bcr-Abl
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背景
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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALL, CML, PHL, BCR1, D22S11, D22S662
Protein Size: 313 -
分子量
- 34 kDa
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基因ID
- 613
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NCBI登录号
- NM_004327, NP_004318
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UniProt
- P11274
抗原
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