Oncogene Protein p190/bcr-Abl (N-Term) 抗体
适用: 人, 小鼠, 兔, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, 马
WB
宿主: 兔
Polyclonal
unconjugated
1 image
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- 抗原
- Oncogene Protein p190/bcr-Abl
- 抗原表位
- N-Term
- 适用
- 人, 小鼠, 兔, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
- 应用范围
- Western Blotting (WB)
- 序列
- EDFSSGQSSR VSPSPTTYRM FRDKSRSPSQ NSQQSFDSSS PPTPQCHKRH
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%
- 产品特性
- This is a rabbit polyclonal antibody against BCR-ABL1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of human BCR
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- Oncogene Protein p190/bcr-Abl
- 别名
- ABL antibody, JTK7 antibody, bcr/abl antibody, c-ABL antibody, p150 antibody, v-abl antibody, ABL proto-oncogene 1, non-receptor tyrosine kinase antibody, ABL1 antibody
- 背景
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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALL, CML, PHL, BCR1, D22S11, D22S662
Protein Size: 313 - 分子量
- 34 kDa
- 基因ID
- 613
- NCBI登录号
- NM_004327, NP_004318
- UniProt
- P11274
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