Spartan 抗体 (C-Term)
Quick Overview for Spartan 抗体 (C-Term) (ABIN2791211)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- QIKSSGNDPK YSTTTAQNSS SSSSQSKMVN CPVCQNEVLE SQINEHLDWC
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预测反应
- Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against SPRTN. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPRTN
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anti-Chromosome 1 Open Reading Frame 124 (C1orf124) antibody
C1orf124 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-240) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-239) antibodyC1orf124 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 1-489) antibodyC1orf124 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 1 Open Reading Frame 124 (C1orf124) (AA 186-235) antibodyC1orf124 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
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别名
- SPRTN
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背景
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SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alias Symbols: C1orf124, DDDL1880, PRO4323, Spartan, dJ876B10.3
Protein Interaction Partner: H2BFS, UBR5, FAM120A, STRAP, CKAP4, MAGED2, HIST2H2BF, HIST1H2BK, POLD4, ZC3HAV1, POLD3, DDX17, SYNCRIP, TRIM28, LRPPRC, HUWE1, HNRNPDL, AKAP12, RBM39, H1FX, HIST1H2BH, HIST1H2BM, HIST1H2BN, HIST1H2BL, HIST1H2BG, VIM, VDAC1, UBB, TUFM, DNAJC7, TMPO, STAU1
Protein Size: 489 -
分子量
- 55 kDa
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基因ID
- 83932
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NCBI登录号
- NM_032018, NP_114407
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UniProt
- Q9H040
抗原
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