DEF6 抗体 (C-Term)
Quick Overview for DEF6 抗体 (C-Term) (ABIN2790082)
抗原
See all DEF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3
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anti-Differentially Expressed in FDCP 6 Homolog (DEF6) antibody
DEF6 适用: 人 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) (AA 1-336) antibodyDEF6 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) antibodyDEF6 适用: 人, 犬, 猴 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) antibodyDEF6 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) (AA 20-114) antibodyDEF6 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) (AA 1-631) antibodyDEF6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Differentially Expressed in FDCP 6 Homolog (DEF6) (N-Term) antibodyVerified DEF6 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))
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别名
- DEF6
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背景
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This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Alias Symbols: C6.1A, BRCC36, CXorf53
Protein Size: 376 -
分子量
- 41 kDa
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基因ID
- 79184
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NCBI登录号
- NM_001018055, NP_001018065
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UniProt
- P46736
抗原
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