Macrophage Scavenger Receptor 1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for Macrophage Scavenger Receptor 1 抗体 (N-Term) (ABIN2789552)
抗原
See all Macrophage Scavenger Receptor 1 (MSR1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
原理
- MSR1 Antibody - N-terminal region
-
序列
- VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN
-
预测反应
- Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%
-
产品特性
- This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.
-
纯化方法
- Affinity Purified
-
-
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 211-320) antibody
MSR1 适用: 人 WB, FACS, IHC (fro), IF (cc), IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 275-451) antibodyMSR1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5B8H4 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) antibodyMSR1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 336-364), (C-Term) antibodyMSR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36746 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) antibodyMSR1 适用: 小鼠, Pig, Catfish (Ictalurus) WB, ELISA, FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal 2F8 unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 271-446) antibodyMSR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Scavenger Receptor 1 (MSR1) (AA 121-220) antibodyMSR1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G9 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63579-100UG
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- prevent freeze-thaw cycles
-
储存条件
- 4 °C,-20 °C
-
储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
-
- Macrophage Scavenger Receptor 1 (MSR1)
-
别名
- MSR1
-
背景
-
Background Information: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Gene Name: Macrophage scavenger receptor 1
Alternative Symbols: SRA, SR-A, CD204, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII
Protein Name: Macrophage scavenger receptor types I and II
-
分子量
- 50kDa
-
基因ID
- 4481
-
NCBI登录号
- NP_619729
-
UniProt
- P21757
抗原
-
