BRE 抗体 (C-Term)
Quick Overview for BRE 抗体 (C-Term) (ABIN2789082)
抗原
See all BRE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against BRE. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 51-229) antibody
BRE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) antibodyKO Validated BRE 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 94-383) antibodyBRE 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 9-338) antibodyBRE 适用: 人, 小鼠 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibodyBRE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibodyBRE 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, Hamster, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 1-415) antibodyBRE 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (N-Term) antibodyBRE 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 383 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
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别名
- BRE
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背景
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BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: FAM175B, UBC, BABAM1, AKAP2, TFG, OPTN, HNRNPA2B1, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, UBD, GFI1B, UIMC1, BRCC3, FAM175A, NCOA3, COPS5, SUMO1, TNFRSF1A, FAS, MMS19, UGGT2, TMX3, DHRS7B, FKBP8, TTC28, ATG2A, SLC25A13, LRPPRC, USP7, SSR3, SHMT2, RPN2, PHB, UB
Protein Size: 383 -
分子量
- 43 kDa
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基因ID
- 9577
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NCBI登录号
- NM_199194, NP_954664
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UniProt
- Q9NXR7
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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