EXOSC9 抗体 (N-Term)
Quick Overview for EXOSC9 抗体 (N-Term) (ABIN2789034)
抗原
See all EXOSC9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- ERRFLLRAIE EKKRLDGRQT YDYRNIRISF GTDYGCCIVE LGKTRVLGQV
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against EXOSC9. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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anti-Exosome Component 9 (EXOSC9) antibody
EXOSC9 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 9 (EXOSC9) (N-Term) antibodyEXOSC9 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 斑马鱼, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 9 (EXOSC9) antibodyEXOSC9 适用: 人 DB 宿主: 小鼠 Monoclonal 2337C3a unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 355 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- EXOSC9 (Exosome Component 9 (EXOSC9))
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别名
- EXOSC9
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背景
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EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
Alias Symbols: PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6
Protein Interaction Partner: UBC, EXOSC4, MPG, AICDA, CSNK2A1, EXOSC5, EXOSC10, EXOSC3, EXOSC2, DIS3, DIS3L, CHMP4B, CAND1, COPS5, CUL3, SUMO2, UBE2I, EXOSC1, SKIV2L2, EXOSC6, DDX39A, MPP6, EXOSC7, EXOSC8, EXOSC9, DDX39B,
Protein Size: 355 -
分子量
- 39 kDa
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基因ID
- 5393
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NCBI登录号
- NM_005033, NP_005024
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UniProt
- Q06265
抗原
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