PKN2 抗体 (C-Term)
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- 抗原 See all PKN2 抗体
- PKN2 (Protein Kinase N2 (PKN2))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠, Cow, 马, 兔, 斑马鱼, 犬, 豚鼠, Saccharomyces cerevisiae
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE
- 预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%
- 产品特性
- This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2
- Top Product
- Discover our top product PKN2 Primary Antibody
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anti-Protein Kinase N2 (PKN2) antibody
PKN2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1D1 unconjugated
anti-Protein Kinase N2 (PKN2) (AA 580-679) antibodyPKN2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-Protein Kinase N2 (PKN2) antibodyPKN2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 925-969) antibodyPKN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 67-312) antibodyPKN2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 108-141) antibodyPKN2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB50147 unconjugated
anti-Protein Kinase N2 (PKN2) (AA 605-654) antibodyPKN2 适用: 人, Cow, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 891-940) antibodyPKN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) antibodyPKN2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 323-464) antibodyPKN2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PKN2 (Protein Kinase N2 (PKN2))
- 别名
- Pkn2 (PKN2 产品)
- 别名
- PAK2 antibody, PRK2 antibody, PRKCL2 antibody, PRO2042 antibody, Pak-2 antibody, 6030436C20Rik antibody, AI507382 antibody, Prkcl2 antibody, Stk7 antibody, pak2 antibody, prk2 antibody, pak-2 antibody, pro2042 antibody, PKN2 antibody, si:ch211-83f14.1 antibody, wu:fa97c07 antibody, protein kinase N2 antibody, protein kinase N2 L homeolog antibody, PKN2 antibody, Pkn2 antibody, pkn2.L antibody, pkn2 antibody
- 背景
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Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983 - 分子量
- 111 kDa
- 基因ID
- 109333
- NCBI登录号
- NM_178654, NP_848769
- UniProt
- Q8BWW9
- 途径
- Cell-Cell Junction Organization
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