PKN2 抗体 (C-Term)
Quick Overview for PKN2 抗体 (C-Term) (ABIN2788942)
抗原
See all PKN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2
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anti-Protein Kinase N2 (PKN2) antibody
PKN2 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1D1 unconjugated
anti-Protein Kinase N2 (PKN2) (AA 580-679) antibodyPKN2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-Protein Kinase N2 (PKN2) antibodyPKN2 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 925-969) antibodyPKN2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 67-312) antibodyPKN2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 108-141) antibodyPKN2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB50147 unconjugated
anti-Protein Kinase N2 (PKN2) (AA 891-940) antibodyPKN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) (AA 605-654) antibodyPKN2 适用: 人, Cow, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N2 (PKN2) antibodyPKN2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Protein Kinase N2 (PKN2) (C-Term) antibodyPKN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- PKN2 (Protein Kinase N2 (PKN2))
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别名
- Pkn2
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背景
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Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983 -
分子量
- 111 kDa
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基因ID
- 109333
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NCBI登录号
- NM_178654, NP_848769
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UniProt
- Q8BWW9
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途径
- Cell-Cell Junction Organization
抗原
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