CD13 抗体 (N-Term)
Quick Overview for CD13 抗体 (N-Term) (ABIN2788665)
抗原
See all CD13 (ANPEP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- VGGSQPPDID KTELVEPTEY LVVHLKGSLV KDSQYEMDSE FEGELADDLA
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预测反应
- Dog: 79%, Guinea Pig: 85%, Horse: 86%, Human: 100%, Rabbit: 79%, Rat: 79%
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产品特性
- This is a rabbit polyclonal antibody against ANPEP. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human ANPEP
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 967 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
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别名
- ANPEP
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背景
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Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Alias Symbols: APN, CD13, GP150, LAP1, P150, PEPN
Protein Interaction Partner: UBC, ANPEP, Cep76, TM4SF1,
Protein Size: 967 -
分子量
- 106 kDa
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基因ID
- 290
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NCBI登录号
- NM_001150, NP_001141
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UniProt
- P15144
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途径
- Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
抗原
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